Description

Site Name: USA - Pennsylvania - Upper Providence, Cambridge 300 Technology Square
Posted Date: Sep 12 2025

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.

The Intracellular Targeted Cancer Therapeutics (ITCT) Biology Unit within the Oncology Research Unit is seeking an experienced Cancer Biologist for a Principal Scientist role that will support a growing portfolio of oncology therapeutics. You will design and execute experiments, analyze data, and collaborate with cross-functional teams to drive impactful therapeutic advancements. We value candidates who are detail-oriented, creative, and passionate about improving patients' lives.

Key Responsibilities:
- Provide basic and translational biology support for target validation, drug discovery, and early clinical development of novel small molecule cancer therapies.
- Work independently to design and execute molecular, biochemical, and cellular assays that support target validation and drug discovery.
- Collaborate with multidisciplinary teams, including chemists, biologists, and data scientists.
- Analyze experimental data, interpret results, and present findings to project teams and the Oncology Research Unit.
- Manage externally resourced projects and ensure timely delivery of high-quality data.

Minimum Qualifications:

• Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, or related life sciences field with 2+ years of post-doctoral research experience, or an M.S. degree with 3+ years of Pharmaceutical industry experience.
• Experience designing, executing, and analyzing molecular, biochemical, and cellular biology experiments.
• Experience in cancer biology, signaling pathways, or synthetic lethality.

Preferred Qualifications:

• 2 or more years of drug discovery experience in a biotech or pharmaceutical company.
• Experience in assay development in a drug discovery setting.
• Knowledge of transgene expression and genomic editing techniques, such as CRISPR/Cas9, to study target biology and drug mechanisms.
• Working knowledge of -omic methods (e.g., sequencing, transcriptomics, proteomics) and databases (e.g., DepMap, CCLE, Sanger, etc.).
• Experience working with lab automation including robotic liquid handlers, automated plate readers, etc
• Attention to detail and proficient reasoning skills in experimental design, data analysis, statistical methods, and interpretation.
• Proven track record of scientific achievement through peer-reviewed publications.
• Ability to work efficiently in a fast-paced, collaborative team environment.
• Strong problem-solving skills and ability to work independently.
• Excellent written and verbal communication skills.

Location:
This role is based in the United States and is on-site at either Upper Providence, PA or Cambridge, MA.

Find out more:
Our approach to R&D

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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